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John Wiley & Sons, Inc, 241-278, 1999

According to the mechanism of ototoxicity induced by aminoglycosides introduced previously, prevention of ototoxicity mainly includes two aspects: upstream protection and downstream protection. Upstream prevention refers to blocking of ROS formation or ROS scavenging, inhibition of nitric oxide synthesis, use of NMDA receptors antagonists, and increase of endogenous antioxidant enzymes
Moreover, bioavailability of metals in free ionic form increases at acidic pH whereas reduced at high pH because of precipitation
