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Gemtuzumab ozogamicin, the first approved ADC, primarily utilizes the acid-sensitive cleavage of the hydrazone linker to release cytotoxic agents, whereas the disulfide bond cleavage predominantly occurs during the intramolecular activation of N -acetyl--calicheamicin, which serves to maintain its molecular conformational stability rather than functioning as a release mechanism for the linker [124]
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doi: 10.3390/antiox13070848 181
