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Ethnic variations in UC genetic susceptibility Genetic susceptibility to UC varies among different ethnic groups, reflecting diverse genetic backgrounds and environmental interactions

They report that a chaperone-dependent E3 ubiquitin ligase, STIP1 homology and U-Box containing protein 1 (STUB1) modulates TFEB content by preferentially ubiquitylating its phosphorylated form as a signal for degradation by the 26S proteasome

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