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Across models spanning tendons, ligaments, muscle, bone and the GI (gastrointestinal) tract, the same core mechanisms appear repeatedly, which is either a sign of genuine pleiotropic biology or publication bias

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It has been recognized that the APAP toxicity consists of multi-stages and multi-signaling pathways, including APAP metabolism, oxidative stress, endoplasmic reticulum (ER) stress, autophagy, sterile inflammation, microcirculatory dysfunction, and compensatory liver repair and regeneration

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[PubMed] [Google Scholar] 180.Brinkmann V., Reichard U., Goosmann C., Fauler B., Uhlemann Y., Weiss D.S., Weinrauch Y., Zychlinsky A

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