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Patients who are also suffering from gastrointestinal disorders, such as small intestinal bacterial overgrowth (SIBO), Celiac or Crohns may not be absorbing Vitamin B12 optimally due to an underlying inflammatory load and unfavourable microbiome

The main exception to this rule is the GLP-1 class (like semaglutide, tirzepatide, or retatrutide), which may be used for longer under proper supervision since the studies and pharmacology support extended duration

Adults over 50 who often have reduced stomach acid and therefore absorb less B12

By supporting these metabolic processes, B12 can help your body efficiently convert food into energy, rather than storing it as fat