2018 pilot study liposomal glutathione eur j clin nutr An Open-Label Case Series of Use for Symptomatic Management in Children with Autism Spectrum Disorder Glutathione in Skin Aging and

in the first trial with bortezomib variably combined with plasmapheresis and rituximab showed modest success with a reduction in the immunodominant DSA of 38/44 (86%) highly sensitized patients, successful transplantation of 19/44 (43.2%), and 17/19 (89.5%) of grafts functional at a median follow-up of 436 days (92)

What they found: In normal obese mice: AOD-9604 reduced body fat by 21 % vs placebo, hGH by 24 % The AOD-9604 effect was fully dependent on the 3-adrenergic receptor , in knock-out mice no effect The hGH effect was partly independent of 3-AR , in knock-out mice there was still ~10 % fat reduction AOD-9604 did not raise IGF-1 (control level), whereas hGH raised IGF-1 by 80 % No changes in growth, organ weights (except adipose tissue), fasting insulin Why it matters: The study provided the mechanistic basis for AOD-9604 and confirmed the key business hypothesis: it is possible to separate the lipolytic effect of GH from its growth effect

It is important to take note of the fact that both studies used a specific brand of glutathione, manufactured by the trial funding company

Another promising trend is the investigation of GHK-Cu in regenerative dentistry