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Beyond these classical mechanisms, bilirubin may fundamentally shape PD risk by orchestrating early embryonic development of dopaminergic neurons through key morphogenic signals, thereby ensuring robust neural circuit formation

Authors HW, GW, YF, JL, and MH were employed by Chengdu Huasun Technology Group Inc, LTD

Glossary ACC Acetyl CoA Carboxylase AchE Acetylcholinesterase ADH Alcohol Dehydrogenase ALB Albumin ALD Alcohol-related Liver Disease ALT Alanine Aminotransferase AMPK AMP-Activated Protein Kinase APAP Acetaminophen (Paracetamol) AST Aspartate Aminotransferase ATP Adenosine Triphosphate Bax Bcl-2Associated X protein Bcl-2 B-Cell Lymphoma 2 BIP Binding Immunoglobulin Protein CAT Catalase CYP Cytochrome P450 CYP-2E1 Cytochrome P450 Family 2 Subfamily E Member 1 CCNE1 Cyclin E1 COX4 Cytochrome c Oxidase Subunit IV CPT-1 Carnitine Palmitoyl Transferase-1 dpf Days Post Fertilization DsRed Discosoma Red Fluorescent Protein DILI Drug-Induced Liver Injury DRP1 Dynamin-Related Protein 1 EGFP Enhanced Green Fluorescent Protein ER Endoplasmic Reticulum FAS Fatty Acid Synthase FAO Fatty Acid Oxidation GSH Glutathione GSH-Px Glutathione Peroxidase GSR Glutathione Reductase GST Glutathione-S-Transferase -GT Gamma-Glutamyl Transferase HCD High-Cholesterol Diet HCF High-Cholesterol + High-Fructose Diet HFD High-Fat Diet HFrD High-Fructose Diet HO-1 Heme Oxygenase-1 HMGCR 3-Hydroxy-3-Methylglutaryl-CoA Reductase hpf Hours Post Fertilization IFN- Interferon- IL-1 Interleukin-1 Beta IL-6 Interleukin-6 IL-10 Interleukin-10 INH Isoniazid IAA Iodoacetamide LDL-C Low Density Lipoprotein Cholesterol LC3-II Microtubule Associated Protein 1A/1B-Light Chain 3 II LC 50 Lethal Concentration 50% MASLD Metabolic dysfunction-associated steatotic liver disease MAPK Mitogen Activated Protein Kinase MDA Malondialdehyde MFN2 Mitofusin 2 MPO Myeloperoxidase MRP2/4 Multidrug Resistance-Associated Protein 2/4 NAFLD Non Alcoholic Fatty Liver Disease NASH Non Alcoholic Steatohepatitis NADP/NADPH Nicotinamide Adenine Dinucleotide Phosphate NF-B Nuclear Factor Kappa-B NO Nitric Oxide NQO1 NAD(P)H Quinone Oxidoreductase-1 NRF1 Nuclear Respiratory Factor 1 Nrf2 Nuclear Factor Erythroid 2-Related Factor 2 OF Overfeeding PPAR Peroxisome Proliferator-Activated Receptor PI3K Phosphoinositide 3-Kinase PINK1 PTEN-Induced Putative Kinase 1 ROS Reactive Oxygen Species RXR Retinoid X Receptor SOD Superoxide Dismutase STAT3 Signal Transducer and Activator of Transcription 3 TC Total Cholesterol TG Triglycerides TAA Thioacetamide TBil Total Bilirubin T-AOC Total Antioxidant Capacity TNF- Tumor Necrosis Factor Alpha UCP2 Uncoupling Protein-2 UPR Unfolded Protein Response References 1 Abu-SiniyehA.KhataibehM.Al-ZyoudW.Al HoliM

Finally, subjects were stratified for the GS and control group and matched by age and gender to result in 40 men and 20 women in both groups, respectively, which reflects the occurrence of GS phenotype in the population 15