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Although this study found that inhibiting Nrf2 expression had no significant effect on HO-1 and NQO1 (Fig
O.et al (2006)
ATF5 is normally localized to the mitochondria but under conditions of mitochondrial protein folding stress, increased levels of reactive oxygen species (ROS), or electron transfer chain dysfunction, the ATF5 protein begins to accumulate in the cytosol and is transported into the nucleus where is activates genes in the mtUPR
Journal of Nutritional Science, 45(3), 210-225
