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Description
Denaturation was monitored by observing changes in ellipticity at 222 nm as a function of temperature or GdmCl concentration

In trials that added it to injected insulin, basal insulin requirements fell roughly 60% to 80% while control improved

TB-500s systemic distribution means injection location barely matters for whole-body effects
If switching the route of administration and dosage don't help, you may also have like a substrate issue
