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Authors Note : To push back slightly on Breckas framing peptides work because they successfully bind to specific cell receptors, not because the body recognises them as endogenous metabolites

Opposite to the cytoplasmic reductive shift in C57BL/6J brain with aging driven by decreased pyruvate levels, neurons isolated from a mixed C57BL/6 129 mouse background showed an oxidized total NADPH/NADP + with aging (Ghosh et al., 2014)

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