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Disclosure of interest: Jumpei Kashiwakura, Simone Tanzarella, Patrick Sagastegui, Paul Bentley, Dario Farina: nothing to disclose Poster Session I - RECOVERY, REHABILITATION AND OUTCOME 03.00 - RECOVERY, REHABILITATION AND OUTCOME - 03.03 - PROGNOSIS AND OUTCOME AFTER STROKE P278 - ESOC25-446 STROKE OUTCOMES OF OBESE PATIENTS TREATED WITH THROMBOLYSIS Moritz Kielkopf 1 , Corinne Inauen 2 , Mattia Branca 3 , Martina Gldlin 1 , Adrian Scutelnic 1 , Thomas Meinel 1 , David Seiffge 1 , Andreas Luft 2 , Christoph Globas 2 , Marcel Arnold 1 , Urs Fischer 1 , Simon Jung 1 , Susanne Wegener 4 , Morin Beyeler 1 , Hakan Sarikaya 5 1 Department of Neurology, Inselspital, Bern University Hospital, and University of Bern, Bern, Switzerland, 2 Department of Neurology, USZ, Zrich University Hospital, and University of Zrich, Zurich, Switzerland, 3 CTU Bern, Institute of Social and Preventive Medicine, University of Bern, Bern, Switzerland, 4 Department of Neurology, USZ, Zrich University Hospital, University of Zrich, Zurich, Switzerland, 5 Department of Neurology, Inselspital, Bern University Hospital, University of Bern, Bern, Switzerland, Bern, Switzerland Background and Aims: The impact of obesity on stroke outcomes, known as the obesity paradox, remains debated

This is the same pathway that Semaglutide (Ozempic/Wegovy) targets, and it remains the foundation of modern weight loss pharmacology

Elevated NNMT is linked to: Reduced NAD+ availability Slower mitochondrial function Increased fat storage efficiency Higher risk for insulin resistance By reducing NNMT activity, 5-Amino-1MQ allows the body to maintain higher NAD+ levels, which can support better mitochondrial performance, improved fat oxidation, and more balanced energy metabolism