cannabis and glutathione Behavioral biochemical effects of Sativa and their modulation by antidepressant drugs Cannabis sativa L. Bioactive Compounds

-glutamate-cysteinyl-synthetase or GCL is in part regulated by glutathione feedback inhibition,[26] which can be partially prevented by an excess of glutamic acid that blocks the regulatory site on the enzyme.[25] Thus, if glutathione is exhausted due to OS, exposure to xenobiotics or inflammation, de novo synthesis of glutathione is up-regulated.[26] Inhibition of GS results in the accumulation of -L-glutamyl-L-cysteine that is converted to cysteine and oxoproline by GCT, and then oxoproline is converted to glutamic acid via 5-oxoprolinase reaction by oxoproplinase

What's the difference between oral and IV glutathione

This compound serves not only as an excretable waste but also as one of the main antioxidants in plasma

It's a gradual process