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When these receptors activate, they trigger a series of signals that increase melanin synthesis inside the melanocytes
The earliest known mention of the term Suma is in the Benavides Memorial of 1630 (Ayer 1965:12), which describes the Suma living in the same area as was noted earlier for the Jumano, that is, south and east of El Paso along the Rio Grande
Specifically, the imposed hypertonic stress is also relevant because it is an established marker used to diagnose dry eye disease [26,27,28]
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