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H3K27 trimethylation) Derepress oncogenic gene expression Silence tumor suppressor loci 4.2 Mechanistic Studies In oral squamous carcinoma-associated fibroblasts, NNMT overexpression reduces H3K27 methylation , enabling ETS2 transcription, which then increases VEGFA expression and promotes angiogenesis

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In vitro work using human articular chondrocytes showed dose-dependent increases in type II collagen synthesis and aggrecan (the major cartilage proteoglycan)