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Further, owing to impaired mitochondrial autophagy, leakage of mtDNA and mitochondrial damage-associated molecular patterns (mDAMPs) in the cytoplasm activate an autocrine inflammatory response, which induces inflammatory response in neighboring hepatocytes and Kupffer cells [69]

It is characterized by iron-dependent accumulation of ROS and peroxidation of polyunsaturated fatty acids of membrane phospholipids

2016 Apr 01

Pilot dose-finding: If feasible within your research design, conduct preliminary work with 2-3 different doses to establish dose-response relationships in your specific model rather than assuming published doses translate perfectly