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Please check the Health Quality Ontario website for a list of all publications: Health Quality Ontario 130 Bloor Street West, 10 th Floor Toronto, Ontario M5S 1N5 Tel: 416-323-6868 Toll Free: 1-866-623-6868 Fax: 416-323-9261 Email: [email protected] ISSN 1915-7398 (online) ISBN 978-1-4606-3290-1 Queens Printer for Ontario, 2013 List of Tables List of Figures List of Abbreviations CINAHL EBSCO Cumulative Index to Nursing and Allied Health Literature HQO Health Quality Ontario ODB Ontario Drug Benefit OHIP Ontario Health Insurance Plan OHTAC Ontario Health Technology Advisory Committee OSB Ontario Schedule of Benefits References 1.Health Canada

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One key factor in evaluating clinical translation is determining the optimal dose and safety of that specific therapy