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[14] According to the classical A-F system, GPCRs can be grouped into six classes based on sequence homology and functional similarity: [15] [16] [17] [18] Class A (or 1) (Rhodopsin-like) Class B (or 2) (Secretin receptor family) Class C (or 3) (Metabotropic glutamate/pheromone) Class D (or 4) (Fungal mating pheromone receptors) Class E (or 5) (Cyclic AMP receptors) Class F (or 6) (Frizzled/Smoothened) More recently, an alternative classification system called GRAFS (Glutamate, Rhodopsin, Adhesion , Frizzled/Taste2, Secretin) has been proposed for vertebrate GPCRs