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Interferon- signaling synergizes with LRRK2 in neurons and microglia derived from human induced pluripotent stem cells

2026 Mar 18:e22690

Using that approach, researchers observed that whole body, neuron-specific, muscle-specific, intestine-specific, and fat-body-specific reduction of methionine significantly extended life when flies were on a standard diet

INH is mainly metabolized in the liver through two major pathways to metabolites such as acetyl isoniazid (AcINH), hydrazine (Hz), acetyl hydrazine (AcHz), diacetyl hydrazine (DiAcHz), and isonicotinic acid (INA), primarily mediated by arylamine N-acetyl transferase2 (NAT2) and amidases (Wang et al., 2016