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Identification, localization, and function in steroidogenesis of PAP7: a peripheral-type benzodiazepine receptor-and PKA (RIalpha)-associated protein
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[DOI] [PubMed] [Google Scholar] [45].Duan J, Karmazyn M

(Lin et al., 2013) depicted that the low potency of LNPs containing DLinDAP can be attributed to hydrolysis caused by endogenous lipases after cell internalization, while DLin-KC2-DMA, DLin-K-DMA, or DLin-DMA, which do not contain ester linkage, were less vulnerable to lipase digestion and facilitated better gene silencing when used in a GAPDH siRNA LNP formulation and RAW 264.7 cells
