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In the case of vitamin B 12 there is no UL, as there is no human data for adverse effects from high doses
Its not simply the kidneys "slowing down", its a multifaceted process involving: Chronic inflammation Fibrosis (scar tissue replacing healthy kidney cells) Vascular damage Autoimmune triggers Oxidative stress Reduced regenerative capacity Until now, the primary goal of treatment has been preservation, not restoration
If necessary, creatinine clearance should be closely monitored
