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Subsequent studies focused on the structural modification of 27 afforded a new synthetic triterpenoid inhibitor 2-cyano-3,12-dioxooleana-1,9,-dien-28-oic acid imidazolide ( 28 ) [147]
10.1016/j.abb.2014.12.007 155 YamadaM
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The signs of dependence on acetaminophen-opioid drugs are increased tolerance, withdrawal symptoms, and compulsive use despite negative consequences
