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Regular exercise, while it increases reactive oxygen species temporarily, can upregulate GPx expression over time as an adaptive response, strengthening cellular defenses
J Coll Physicians Surg Pak
[DOI] [PubMed] [Google Scholar] Ju W
Under oxidative damage conditions, Nrf2 transports to the nucleus, then binds to the antioxidant response element (ARE), and enhances sequence to initiate transcription of cytoprotective genes NF-E2 related factor 2 (Nrf2) has been seen to get modulated in various neurodegenerative diseases
