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In RBCs, NADPH are produced exclusively via HMP shunt by the action of G6PD and are responsible to maintain membrane integrity preventing premature destruction

Discussion Here we used a combination of molecular modelling, biochemistry, in vitro and in vivo experiments to specifically target FOXO4 in the FOXO4-TP53 interaction and show induction of apoptosis of senescent cancer cells

also demonstrated the effects of SFN (25 mg/kg) administered orally, in C57BL/6 mice with Alzheimer-like lesions induced by the combined treatment of D-galactose (200 mg/kg), via subcutaneous and aluminum chloride dissolved in water (0.4 g/100 mL)