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However, it is noteworthy that ten oligonucleotide drugs have been officially approved by FDA as of January 2020 [55], which means that the technological obstacles for oligonucleotide therapeutics are being solved step by step and the development of oligonucleotide drugs targeting NNMT is still a promising method for the prevention or treatment of obesity and related T2D in the future

These properties suggest potential benefits for autoimmune diseases that damage joints or gut mucosa

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Thus, equal time-periods of ischemia and reperfusion were involved (60 min/60 min for grade III and 30 min/30 min for grade IV)