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Oocyte Maturation Rate: It is generally related to nuclear maturity, being defined as the proportion of oocytes at MII stage ( Normal fertilization: Defined as the appearance of two protonuclei and two polar bodies at 16~18h after insemination ( Day three (D3) top-quality embryos: They are generally defined as those originating from normally fertilized oocytes with a cell count of 79 on day three after fertilization, the fragmentation rate is less than 10%, and there are no multinucleated embryos ( Blastocyst formation rate: Defined as the proportion of 2PN zygotes (not just of cleaved zygotes) which are at the blastocyst stage at Day 5 (116 2 h post-insemination) ( Usable blastocyst rate: This term denotes the combined count of transferred and frozen blastocysts within a single oocyte retrieval cycle

The acyl-CoA undergoes sequential -oxidation, generating acetyl-CoA that enters the tricarboxylic acid (TCA) cycle for energy production or converts to ketone bodies in hepatic mitochondria (15, 23)

In animal studies, offspring with prenatal exposure to valproate had malformations similar to those seen in humans and demonstrated neurobehavioral deficits [see Use in Specific Populations (8.1)]