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However, the modelling of chemical toxicology and in particular metabolic processes in vitro is fraught with many challenges, including the use of a proliferating rather than a quiescent cell, limited retention of metabolic activities in immortalised cell lines, and the poor recapitulation of the in vivo metabolic environment and substrate availability

Specifically, HIF-1 exerts a crucial influence on synovial inflammation, angiogenesis, and regulation of cellular metabolism in RA, among other processes

It is used in research examining somatotropic signaling and peptide-receptor interactions in vitro

It also enhanced the migration and spreading of tendon fibroblast in a dose-dependent manner