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Zavegepant exhibited potent inhibition (K i = 23 pM) of CGRP binding to human CGRP receptor expressed in cell membranes and demonstrated potent and full reversal of CGRP-induced dilation of ex vivo human intracranial arteries (EC 50 =880 pM)

doi: 10.1111/j.1524-475X.2009.00552.x

[DOI] [PubMed] [Google Scholar] 89.Salares V.R., Young N.M., Bernstein H.J., Carey P.R

In skincare, it is used in two major ways: topically with skincare products and orally with supplements