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Gastrointestinal conditions Some gastrointestinal conditions may affect how vitamin B12 is digested or absorbed, such as: history of gastrointestinal surgery celiac disease Crohns disease pernicious anemia infections, such as from Helicobacter pylori bacteria or parasites pancreatic insufficiency or cancer bowel cancer folic acid deficiency small intestinal bacterial overgrowth Vitamin B12 injections may be more helpful for people with gastrointestinal conditions than oral products

Patients often report a wide range of positive effects, such as increased energy and stamina, sharper mental clarity, improved mood, and better quality of sleep

This combination improved hypothalamic inflammation, astrocytosis, microgliosis, and insulin sensitivity

A cross-sectional study that compared 45 cases of NAFLD with 30 healthy controls found lower vitamin B12 in patients with grade 2 and grade 3 of liver steatosis 8