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Materials All of the reagents were used as supplied

[1] The NHS advises that taking up to 2mg (2000 micrograms) per day of vitamin B12 supplements is unlikely to cause harm

therefore, calcium supplementation is not currently prescribed for the prevention or treatment of metformin-induced vitamin B 12 deficiency (145)

However, prescribers must be aware that the FDA issued a safety alert in April 2025 specifically addressing compounded topical finasteride
