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The authors concluded that due to the high prevalence of MTHFR variants and how crucial it is to assure pregnant women get adequate supplementation, L-methylfolate may be the best option to avoid blood folate deficiencies. The study also notes that excessive ingestion of folic acid could mask an undiagnosed B12 deficiency, and that it was unlikely that methylfolate would mask a B12 deficiency in the same way

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Scientific literature also references research frameworks examining metabolic signaling models and cellular responses to peptide-mediated signaling within metabolic regulatory systems