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Recent studies have shown that iron release via NCOA4-mediated ferritinophagy supported synthesis of ISC proteins and mitochondrial respiration, which are critical for PDAC growth [6]
The aryl hydrocarbon receptor (AHR) is a ligand-activated transcription factor that regulates gene expression associated with various physiological and pathological processes, including xenobiotic metabolism, tissue development, immune response, and cellular proliferation 28

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