what does glutathione do for parkinson& 39 Frontiers Frontiers | Recent advances in
Description
The fact that the syndrome presents a range of severity and variability in its clinical manifestations and a high genetic heterogeneity makes the development of disease models difficult, which have been limited to specific mutations
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However, mtDNA is particularly vulnerable to damage due to its proximity to the ROS-generating electron transport chain (ETC), lack of protective histones, and relatively inefficient repair mechanisms (15, 16)
A medication that is pharmacologically appropriate may still fail clinically if it increases reactivity
