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Similarly, in BMDMs, pharmacological inhibition of LRRC8 (with DCPIB) impaired volume-activated chloride currents, cell volume change and IL-1 release after hypotonic challenge (supp

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The ROS generated through radiolysis of cellular water and the free iron take part in the Fenton reaction-mediated lipid peroxidation of the plasma membrane and finally cell death through ferroptosis (Fig