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A deficiency in thiamine (B1) or riboflavin (B2) impairs energy metabolism and can contribute to fatigue, poor focus, or cognitive fog
10.1038/s42003-021-01820-z Commun Biol
1IK), further confirming the requirement for an intact TGF pathway
They next experimented with injecting old animals with a small molecule drug that inhibits 15-PGDH activity first into the abdomen, which affects the entire body, then directly into the joint
