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When iron overloads, hypoxia-inducing factor (HIF) is degraded and down-regulates iron-regulatory protein (IRP), which binds to iron-regulatory elements (IRE) linked to iron metabolism in brain tissue, inhibits the translation of TfR1 and DMT1 and promotes the translation of ferritin, FPN1, and APP (Rogers et al
Glutathione and Liver Diseases 5.1
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Molecules 26: 4021 Khera AV, Emdin CA, Drake I, Natarajan P, Bick AG, Cook NR, Chasman DI, Baber U, Mehran R, Rader DJ, Fuster V, Boerwinkle E, Melander O, Orho-Melander M, Ridker PM, Kathiresan S (2016) Genetic risk, adherence to a healthy lifestyle, and coronary disease
