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For instance, during myeloid cell development, C/EBP can be directly phosphorylated by ERK1/2 on S21, and this phosphorylation leads to a conformational change in C/EBP, which in turn increases the distance between the amino termini of the C/EBP dimer, affecting the action on target molecules and leading to an alteration in the differentiation potential of haematopoietic precursor cells in favour of granulocyte development while inhibiting monocyte differentiation [75]