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Therefore, complex I inhibition can exert both pro- and antiferroptotic effects: promoting ferroptosis via ubiquinol (CoQ 10 H 2 ) depletion, while simultaneously suppressing it through AMPK activation
In particular, inhibition of IL-1 by canakinumab, the monoclonal antibody (Mab), had a positive therapeutic effect
Future research must concentrate on targeted delivery, combination medicines, and biomarker discovery to tackle the problems and future trajectories of antioxidants in cancer therapy
[DOI] [PMC free article] [PubMed] [Google Scholar] 79.Di Pierro F., Rossi A., Consensi A., Giacomelli C., Bazzichi L
