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Many clinical and preclinical studies have proven the beneficial effects of berberine in diabetes mellitus, mainly due to its ability to enhance insulin expression and potential antioxidant effects, as well as improving spatial reminiscence impairment in diabetic rats (116)

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This might be because their meals are less healthy or because they have less stomach acid, which is required for B12 absorption

[2] Neurogenic bladder can cause urinary retention and cause symptoms similar to those of BPH