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10.1016/j.cej.2020.126004 322 YangX.JiaH.XingW.LiF.LiM.SunK.et al (2019)
However, human epidemiological evidence for transgenerational effects remains limited, primarily due to the extended timeframes required for multigenerational studies and the practical challenges of maintaining long-term cohorts across decades ( Low-Dose Chronic Exposure Effects Present Assessment Challenges EEDs frequently exhibit non-monotonic dose-response (NMDR) patterns, where low-dose chronic exposure may produce more pronounced biological effects than acute high-dose exposure

Urology 73 , 421426 (2009)
