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Furthermore, irisin activated the SIRT1 signaling pathway, leading to the deacetylation of HIF-1 and PGC-1, which suppressed apoptosis and enhanced cell viability in MPP + -treated SH-SY5Y cells

Suh WS, Eksioglu-Demiralp E, Kitada S, Andreeff M , Champlin RE, Reed JC

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Pretreatment with Zn(II)-BnPyP or Cu(II)-BnPyP significantly reduced PrP levels and Cu toxicity in ATP7B-KO cells (Supplementary Fig
