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Elevated levels are often an early indicator of B12 insufficiency

Edaravone Edaravone, approved in Japan (2015) and the US (2017), represents another major pharmacological option, particularly indicated for early-stage ALS (23)

The capsules can be easily swallowed and assimilated in the body and, therefore, very convenient to incorporate into our daily lives

Cell culture and stimulation Normal human epidermal keratinocytes (NHEKs) were purchased from Takara Bio (Shiga, Japan) and cultured in Keratinocyte Basal Medium (KBM) overnight prior to human recombinant rIL-22 stimulation (200 ng ml 1 , R&D Systems, Minneapolis, MN)