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Initially, the mechanisms of action of this enzyme were considered paradoxical because CD38 is predominantly localized on the cell surface, yet its final products are utilized within cytoplasmic compartments

Evidence has revealed that MDA, a marker of lipid peroxidation, was increased in patients with NAFLD 32,33

LDL, or low-density lipoprotein, isn't inherently 'bad.' Its job is to transport cholesterol from the liver to cells that need it for building membranes and producing hormones

The core concept is that normal components of the tissue (or of the niche where the tumor grows) may provide, either occasionally or as part of a precise neoplastic strategy, a set of soluble factors that contribute to, or even determine, the growth of the tumor itself or facilitate immune evasion