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Studies show significantly increased collagen, reticulin, and blood vessel formation[9]

44 An open-label, uncontrolled trial in 51 patients with myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS) found improvements in 34 patients after 3 months of supplementation with hydroxo-B12, 10 000 mcg twice per week as nasal drops

According to the Selank's package insert, the dosage is two drops given three times a day (usually morning, noon, and evening) for up to two weeks, followed by a week of washout and another two weeks of therapy if needed

We also reviewed relevant references cited in retrieved articles and review articles