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Ferroptosis has been reported to be inhibited by p53 in colorectal cancer cells through the formation of a dipeptidyl peptidase-4 (DPP4)-p53 complex and the subsequent translocation of the DPP4 enzyme from the cell membrane to the nucleus

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Epithelial cells express NOX1 and DUOX2, which produce ROS into the extracellular space or gut lumen (121123), whereas phagocytes (neutrophils, eosinophils, macrophages) express NOX2 (phagocyte oxidase) that produces superoxide inside phagosomes or can leak it outside (124, 125)