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Both are engineered modifications of the native sequence designed to overcome specific limitations of standard IGF-1 particularly its rapid sequestration by insulin-like growth factor binding proteins (IGFBPs)

OMICS : A Journal of Integrative Biology, 20 (3), 127138
Research shows glutathione supplementation significantly upregulates expression of antioxidant response element (ARE)-containing genes including heme oxygenase-1, superoxide dismutase, and catalase

doi: 10.1016/j.semnephrol.2012.04.003