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Description
This often leads to painful and/or disruptive symptoms in the feet and lower legs but these symptoms may also progress to other parts of the body

The inflammatory processes in IBD create a self-perpetuating cycle that further exacerbates ENS dysfunction, reinforcing disease chronicity

TNF- disrupts the BBB by inducing C-X-C motif chemokine ligand 10 (CXCL10) secretion and promoting peripheral T lymphocyte infiltration

doi: 10.1016/j.conb.2021.09.005
