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If neurological symptoms are present, treatment is more intensive: 1 mg on alternate days until no further improvement occurs, then maintenance doses of 1 mg every 2 months
Inhibition of cco-1 is a well-known intervention that, similarly to mrps-5 RNAi, activates the UPR mt and extends lifespan in worms 21
Cell (2017) 171:201216.e18
