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For that reason, an untreated pernicious anemia often leads to neurological damage, which should explain why so many patients with neurological disorders such as Alzheimer, multiple sclerosis, peripheral neuropathy, and Bells Palsy, benefit from B12 shots
Larger than normal doses of digoxin are required, but there is probably no change in the toxic-to-therapeutic dose ratio
Mechanistically, p53 forms a complex with DPP4 and promotes the nuclear accumulation of DPP4
doi: 10.1083/jcb.201701085
