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Synthesis: While some older trials and meta-analyses suggest silymarin may improve biochemical markers in alcoholic liver disease, the evidence base is inconsistent, and major hepatology guidelines do not recommend it

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In addition, heterogeneity may be further introduced by the use of different assays for ferroptosis (e.g., GPX4 activity, levels of lipid peroxidation, MDA assays) and by variations in endpoint definitions

Biochimica Biophysica Acta 32, 579581