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Serum B12, methylmalonic acid, and homocysteine directly reflect B12 status and methylation capacity

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These systems allow targeted delivery of therapeutic nucleic acids, such as GPX4 mRNA to enhance antioxidant capacity or ACSL4-siRNA to limit peroxidation-prone lipid pools (164), enabling cell-type-specific suppression of ferroptosis

Thus, RIDD modulates the adaptive response to hypoxia (Moszynska et al
